The first term, \(4x^2\text{,}\) is a perfect square because it equals \((2x)^2\text{.}\) So we could take \(A=2x\text{.}\) The last term, \(25y^2\text{,}\) is also a perfect square since it is equal to \((5y)^2\text{.}\) So we could take \(B=5y\text{.}\) Now we multiply \(2AB=2\cdot (2x)\cdot(5y)\text{,}\) and the result is \(20xy\text{.}\) This is the negative of the middle term, which we can work with. The factored form will be \((A-B)^2\) instead of \((A+B)^2\text{.}\)
\begin{align*}
4x^2-20xy+25y^2\amp=(A-B)^2\\
\amp=(2x-5y)^2
\end{align*}